Proliferative, degradative smooth muscle cells promote aortic disease
نویسندگان
چکیده
منابع مشابه
Dispersed Aortic Smooth Muscle Cells
Studies on hormone induced contraction of vascular smooth muscle strips in vitro have yielded a large body of pharmacological and biochemical data (1). Unfortunately, vascular strips possess inherent limitations for answering certain questions concerning sites of hormone binding on their constituent smooth muscle cells. Diffusion barriers in the tissue may hinder the use of macromolecular recep...
متن کاملAdipose Stem Cells Promote Smooth Muscle Cells to Secrete Elastin in Rat Abdominal Aortic Aneurysm
BACKGROUND Abdominal aortic aneurysm (AAA) is a life-threatening disease and its prevalence rate increases with social aging. The degradation of elastic is an important factor in the formation of AAA. METHODS Adipose derived stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMSCs) were isolated from rats, and identified by Oil red O and alizarin red staining after adipogenesis and os...
متن کاملAging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells.
The cellular mechanisms that contribute to the acceleration of atherosclerosis in aging populations are poorly understood, although it is hypothesized that changes in the proliferative capacity of vascular smooth muscle cells is contributory. We addressed the relationship among aging, generation of reactive oxygen species (ROS), and proliferation in primary culture smooth muscle cells (SMC) der...
متن کاملIntegrin Receptors on Aortic Smooth Muscle Cells
Extracellular matrix receptors on vascular smooth muscle cells help in anchoring the cells during contraction and in promoting cellular migration after vessel injury. We found that rat aortic smooth muscle cells attach to surfaces coated with fibronectin, laminin, and collagen types I and IV. Cell attachment to these substrates appears to be mediated by members of the f1 integrin family of extr...
متن کاملCytodifferentiation and expression of alpha-smooth muscle actin mRNA and protein during primary culture of aortic smooth muscle cells. Correlation with cell density and proliferative state.
To investigate a possible correlation between cytodifferentiation, proliferation, and actin expression, smooth muscle cells from the 9-week-old rabbit aortic media were enzyme-dispersed into single cells and were plated in primary culture at different initial seeding densities. The volume fraction of myofilaments (Vv myo) in cells seeded moderately densely fell from 39.5% +/- 1.2% in the intact...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2020
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci134019